what to do with和how to deal with的区别：how to deal with it这是对方式状语提问的，用什么方法去处理；what to do with it这是对内容提问的， 对它，如何处理——指要做些什么。
what to do with和how to deal with区别
1.Do with 与deal with 都可作“处置”讲。do with 常与连接代词what连用，而deal with 常与连接副词how连用。
2.状语是谓语中心前面的修饰语，表示的是时间、处所、方式、条件、对象等等，可见，从语义上看，状语的功能之一就是表示方式。方式状语从句多用来谈论某人的行为或者做某事的方式。
3.what to do"做什么"问的是动作的对象，what是代词，how to do "怎样做"问的是动作的方式，how是副词。what to do中不需要加宾语。how to do 中how做to do的状语需要加宾语。
what to do with造句：
The children didn't know what to do with themselves as Christmas drew near.
圣诞节即将到来，孩子们坐立不安了。
The government appears to be in a quandary about what to do with so many people.
政府似乎陷入了左右为难的境地，不知道该拿这么多人怎么办。
Was there a difference of opinion over what to do with the Nobel Prize money?
在如何利用那笔诺贝尔奖金的问题上有不同意见吗？
The play was terrible; half the actors didn't know what to do with their hands.
这个剧演得糟极了，一半演员连手都不知怎么放。
I don't know what to do with the problem.
我不知道如何处理这个问题。